Insulin receptor substrate-1 Gly972Arg variant and type 2 diabetes mellitus
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منابع مشابه
Insulin receptor substrate-1 Gly972Arg variant and type 2 diabetes mellitus.
Insulin receptor substrate-1 Gly972Arg variant and type 2 diabetes mellitus To the Editor: In their article, Vergotine et al.[1] concluded that ‘the Gly972Arg variant may not aid diabetes risk evaluation in this setting’. In fact, the insulin receptor substrate-1 Gly972Arg variant is widely studied in terms of its relationship to diabetes mellitus. Different observations have been made in diffe...
متن کاملNo evidence for association of insulin receptor substrate-1 Gly972Arg variant with type 2 diabetes mellitus in a mixed-ancestry population of South Africa.
BACKGROUND The most common single-nucleotide polymorphism in the insulin receptor substrate-1 (IRS1) gene is Gly972Arg, which is associated with a 25% increased risk of developing diabetes. The mixed-ancestry population of South Africa (SA) has one of the highest prevalences of type 2 diabetes mellitus (T2DM) in Africa. OBJECTIVE To report the frequency of IRS1 Gly972Arg and investigate its a...
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متن کاملMolecular scanning for mutations in the insulin receptor substrate-1 (IRS-1) gene in Turkish with type 2 diabetes mellitus.
Insulin receptor substrate-1 (IRS-1) is an endogenous substrate for the insulin receptor tyrosine kinase, which plays a key role in insulin signaling. Recent studies have identified several polymorphisms in the human IRS-1 gene (Irs-1) that are increased in prevalence among type 2 diabetic patients. To determine whether variation in the Irs-1 contributes to genetic susceptibility to type 2 diab...
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ژورنال
عنوان ژورنال: South African Medical Journal
سال: 2014
ISSN: 2078-5135
DOI: 10.7196/samj.8922